Injectable thermoreversible hyaluronan-based hydrogels for nucleus pulposus cell encapsulation
نویسندگان
چکیده
منابع مشابه
Fibrous protein-based hydrogels for cell encapsulation.
Tissue scaffolds play a vital role in tissue engineering by providing a native tissue-mimicking environment for cells, with the aim to promote cell proliferation, proper cell differentiation, and regeneration. To better mimic the microenvironment of native tissues, novel techniques and materials have emerged in recent years. Among them, hydrogels formed from self-assembled biopolymer networks a...
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Cell delivery to the pathological intervertebral disc (IVD) has significant therapeutic potential for enhancing IVD regeneration. The development of injectable biomaterials that retain delivered cells, promote cell survival, and maintain or promote an NP cell phenotype in vivo remains a significant challenge. Previous studies have demonstrated NP cell - laminin interactions in the nucleus pulpo...
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We developed a nucleus pulposus cell (NPC)-modulated decellularized small intestinal submucosa (SIS) scaffold, and assessed the ability of this material to prevent Intervertebral disc degeneration (IVD) degeneration. Decellularized porcine SIS was squashed into particles and the biological safety and efficiency of these particles were evaluated. Next, SIS particles were seeded with rabbit NPCs,...
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Bioadhesive polymers are natural or synthetic materials that can be used for soft tissue repair. The aim of this investigation was to develop an injectable, bioadhesive hydrogel with the potential to serve as a synthetic replacement for the nucleus pulposus of the intervertebral disc or as an annulus closure material. Branched copolymers of poly(N-isopropylacrylamide) (PNIPAAm) and poly(ethylen...
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Introduction Current procedures to repair bone loss in the oral cavity require the use of autogenous bone transplants, bone substitute materials and/or additional devices such as screws or membranes. Subsequent drawbacks are complex, expensive and time consuming surgeries. Furthermore, there is an unacceptable rate of risks and failures. Hyaluronic acid (HA)-based hydrogels are proven biocompat...
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ژورنال
عنوان ژورنال: European Spine Journal
سال: 2011
ISSN: 0940-6719,1432-0932
DOI: 10.1007/s00586-011-1976-2